CD8+ T cells specific to apoptosis-associated epitopes are expanded in patients with chronic HBV infection and fibrosis.

Ilenia PacellaIlenia CammarataCarmela MartireGiuseppina BrancaccioGiovanni Battista GaetaVincenzo BarnabaSilvia Piconese

Published in: Liver international : official journal of the International Association for the Study of the Liver (2020)

All together, these findings indicate a link between AE-specific CD8+ T cells and advanced liver fibrosis in patients with chronic HBV infection, and suggest that virus-specific and AE-specific CD8+ T cells exhibit distinct differentiation states and contribute in distinct ways to immunopathology.

Keyphrases

liver fibrosis
hepatitis b virus
cell death
liver failure
cell proliferation
cell cycle arrest
pi k akt