Orthostatic Hypotension Is a Predictor of Fatigue in Drug-Naïve Parkinson's Disease.

Fatigue is a common NMS in PD but can vary depending on the disease course. OH and depression are the most relevant predictors for the development of fatigue in drug-naïve PD. The present study suggests that the management of autonomic symptoms and depression might be helpful for managing fatigue in PD.