Fadu head and neck squamous cell carcinoma induces hyperexcitability of primary sensory neurons in an in vitro coculture model.
Megan L UhelskiAysegul GorurTed ShiGerman CorralesKim N DuYan LiMoran AmitClaudio E TatsuiLaurence D RhinesPatrick M DoughertyJuan P CataPublished in: Pain reports (2022)
Pro-inflammatory substances released in cancer cell-DRG coculture promoted neuronal hyperexcitability and may contribute to cancer pain after PNI, and these effects may differ across age groups and sexes.