Repeat length variations in polyglutamine disease-associated genes affect body mass index.
Sarah L GardinerRenée de MutsertStella TrompetMerel W BoogaardKo Willems van DijkP J Wouter JukemaP Eline SlagboomRaymund A C RoosHanno PijlFrits R RosendaalN Ahmad AzizPublished in: International journal of obesity (2005) (2018)
Our findings incriminate repeat polymorphisms as an important novel class of genetic risk factors of obesity and highlight the role of the brain in its pathophysiology.
Keyphrases
- body mass index
- risk factors
- weight gain
- genome wide
- insulin resistance
- metabolic syndrome
- weight loss
- type diabetes
- resting state
- white matter
- high fat diet induced
- physical activity
- dna methylation
- cerebral ischemia
- functional connectivity
- adipose tissue
- bioinformatics analysis
- multiple sclerosis
- gene expression
- subarachnoid hemorrhage
- genome wide analysis