Inflammatory and antioxidant pattern unbalance in "clopidogrel-resistant" patients during acute coronary syndrome.
Raffaele CarusoSilvia RocchiccioliAnna Maria GoriAntonella CecchettiniBetti GiustiGuido ParodiLorena CozziRossella MarcucciMarina ParoliniIlaria RomagnuoloLorenzo CittiRosanna AbbateOberdan ParodiPublished in: Mediators of inflammation (2015)
In patients with high RPR on clopidogrel therapy, an unbalance of inflammatory factors, platelet adhesion molecules, and circulatory and platelet antioxidant molecules was observed during the acute phase. Proinflammatory milieu persists in nonresponders for a long time after the acute event while antioxidant blood factors tend to conform to normal responsiveness.
Keyphrases
- acute coronary syndrome
- oxidative stress
- percutaneous coronary intervention
- antiplatelet therapy
- anti inflammatory
- end stage renal disease
- ejection fraction
- newly diagnosed
- liver failure
- chronic kidney disease
- peritoneal dialysis
- stem cells
- intensive care unit
- staphylococcus aureus
- escherichia coli
- patient reported outcomes
- drug induced
- respiratory failure
- bone marrow
- aortic dissection
- candida albicans
- mechanical ventilation