Multisite Detection of Tn 1549 -Mediated vanB Vancomycin Resistance in Multidrug-Resistant Enterococcus faecalis ST6 in Texas and Florida.
Shelby R SimarTruc T TranKirsten B RydellDiana PanessoGerman A ContrerasJose M MunitaRenzo O CifuentesLilian M AbboPranoti SahasrabhojaneAn Q DinhDierdre B Axell-HouseTor SavidgeSamuel A Shelburne IiiBlake M HansonCésar A AriasPublished in: Antimicrobial agents and chemotherapy (2022)
In the United States, vanB -mediated resistance in enterococci is rare. We characterized three sequence type (ST) 6, vancomycin-resistant Enterococcus faecalis isolates causing bacteremia in unique patients in spatiotemporally distinct settings. Isolates were recovered between 2018 and 2020 in two cities in the United States (Houston, TX; Miami, FL). The isolates harbored the vanB operon on a chromosomally located Tn 1549 transposon, and epidemiological data suggested multiple introductions of the vanB gene cluster into ST6 E. faecalis.
Keyphrases
- multidrug resistant
- methicillin resistant staphylococcus aureus
- end stage renal disease
- genetic diversity
- ejection fraction
- gram negative
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- drug resistant
- copy number
- staphylococcus aureus
- gene expression
- electronic health record
- big data
- transcription factor
- cystic fibrosis
- machine learning
- quantum dots
- patient reported