Antimicrobial Drug Penetration is Enhanced by Lung Tissue Inflammation and Injury.

Johannes GeilenMatthias KainzBernhard ZapletalAsami NakaJohanna TichyWalter JägerMichaela BöhmdorferMarkus ZeitlingerMarcus J SchultzTanja StammValentin RitschlSilvana GeleffEdda M Tschernko

Published in: American journal of respiratory and critical care medicine (2023)

Tissue penetration of two commonly used antimicrobial drugs for pneumonia is enhanced by early lung tissue inflammation and injury, resulting in longer times above the minimal inhibitory concentration. Thus, lung tissue inflammation ameliorates antimicrobial drug penetration during the acute phase.

Keyphrases

oxidative stress
staphylococcus aureus
emergency department
intensive care unit
drug induced
acute respiratory distress syndrome