Network pharmacology prediction, molecular docking, and molecular dynamics simulation-based strategy to explore the potential mechanism of Huashanshen dripping pill against asthma.
Xiaoyu WangYansu JiXin JinMiaomiao ZhouYujie WuYanhong XuRui LiuJihong FengPublished in: The Journal of pharmacy and pharmacology (2024)
All results suggested that HSS can decrease airway inflammation in asthmatic mice by inhibiting NF-κB signaling pathway. This finding will shed light on how it can be used to treat asthma.
Keyphrases
- molecular docking
- signaling pathway
- molecular dynamics simulations
- lung function
- chronic obstructive pulmonary disease
- pi k akt
- allergic rhinitis
- induced apoptosis
- epithelial mesenchymal transition
- cystic fibrosis
- air pollution
- high fat diet induced
- type diabetes
- oxidative stress
- lps induced
- metabolic syndrome
- risk assessment
- cell proliferation
- nuclear factor
- human health
- wild type
- climate change