Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs.

Yuki MiharaTakuya IshimotoRyosuke OzasaTakao OmuraYu YamatoTomohiro YamadaAyako OkamotoYukihiro MatsuyamaTakayoshi Nakano

Published in: Journal of bone and mineral metabolism (2023)

Lesions in Cckbr-deficient mice occurred earlier in apatite orientation than in bone mass. Hence, bone apatite orientation may be a promising method for detecting hypochlorhydria-induced osteoporosis caused by PPI treatment and warrants urgent clinical applications.

Keyphrases

bone mineral density
postmenopausal women
bone loss
bone regeneration
high glucose
body composition
diabetic rats
genome wide
drug induced
oxidative stress
transcription factor
genome wide identification
dna methylation
replacement therapy
smoking cessation