Multimodality assessment of heart failure with preserved ejection fraction skeletal muscle reveals differences in the machinery of energy fuel metabolism.

Payman ZamaniElizabeth A ProtoNeil WilsonHossein FazeliniaHua DingLynn A SpruceAntonio DavilaThomas C HanffJeremy A MazurekStuart B PrennerBenoit DesjardinsKenneth B MarguliesDaniel P KellyZoltan AranyPaschalis-Thomas DouliasJohn W ElrodMitchell E AllenShana E McCormackGayatri Maria SchurKevin D'AquillaDushyant KumarDeepa ThakuriKarthik PrabhakaranMichael C LanghamDavid C PooleSteven H SeeholzerRavinder ReddyHarry IschiropoulosJulio A Chirinos

Published in: ESC heart failure (2021)

Heart failure with preserved ejection fraction patients demonstrate impaired functional capacity and SkM OxPhos. Reductions in the proportions of Type I myofibres, proteins required for OxPhos, and altered phosphorylation signalling in the SkM may contribute to exercise intolerance in HFpEF.

Keyphrases

skeletal muscle
end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
insulin resistance
physical activity
prognostic factors
high intensity
type diabetes
patient reported outcomes
metabolic syndrome
protein kinase