A naphthalimide-aminal-based pH-sensitive fluorescent donor for lysosome-targeted formaldehyde release and fluorescence turn-on readout.
Huan XuShengnan MaQianqian LiuLixian HuangPeimin WuXiaolin LiuYali HuangXiaolei WangHuan XuKaiyan LouWei WangPublished in: Chemical communications (Cambridge, England) (2019)
A naphthalimide-aminal-based fluorescent donor (NAP-FAD-1) is a pH-sensitive smart donor, which features accelerated FA release at pH 5.0 compared to that at pH 7.4 and fluorescence turn-on readout for facile tracking and quantification of FA release. Confocal imaging studies of HeLa cells co-incubated with Lyso-Tracker Red suggested that its FA release is lysosome-targeted.
Keyphrases
- fluorescent probe
- living cells
- single molecule
- quantum dots
- cell cycle arrest
- cancer therapy
- induced apoptosis
- high resolution
- optical coherence tomography
- photodynamic therapy
- room temperature
- signaling pathway
- gold nanoparticles
- fluorescence imaging
- highly efficient
- ionic liquid
- raman spectroscopy
- metal organic framework