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Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer.

Angela ChouDanielle FroioAdnan M NagrialAshleigh ParkinKendelle J MurphyVenessa T ChinDalia WohlAngela SteinmannRhys StarkAlison DruryStacey N WaltersClaire VenninAndrew BurgessMark PineseLorraine A ChantrillMark J CowleyTimothy J Molloynull nullNicola WaddellAmber JohnsSean M GrimmondDavid K ChangAndrew V BiankinOwen J SansomJennifer P MortonShane T GreyThomas R CoxJohn TurchiniJaswinder SamraStephen J ClarkePaul TimpsonAnthony J GillMarina Pajic
Published in: Gut (2017)
This study demonstrates the promise of CDK4 inhibition in PDA over standard therapy when applied in a molecular subtype-specific context.
Keyphrases
  • cell cycle
  • mouse model
  • cancer therapy
  • mesenchymal stem cells
  • cell proliferation
  • bone marrow
  • drug delivery
  • deep learning
  • cell therapy