Prodrug Polymeric Nanoconjugates Encapsulating Gold Nanoparticles for Enhanced X-Ray Radiation Therapy in Breast Cancer.
Hamed NosratiFarzad SeidiAli HosseinmirzaeiNavid MousazadehAli MohammadiMohammadreza GhaffarlouHossein DanafarJoão CondeAli SharafiPublished in: Advanced healthcare materials (2021)
An optimal radiosensitizer with improved tumor retention has an important effect on tumor radiation therapy. Herein, gold nanoparticles (Au NPs) and drug-containing, mPEG-conjugated CUR (mPEG-CUR), self-assembled NPs (mPEG-CUR@Au) are developed and evaluated as a drug carrier and radiosensitizer in a breast cancer mice model. As a result, cancer therapy efficacy is improved significantly by applying all-in-one NPs to achieve synchronous chemoradiotherapy, as evidenced by studies evaluating cell viability, proliferation, and ROS production. In vivo anticancer experiments show that the mPEG-CUR@Au system improves the radiation sensitivity of 4T1 mammary carcinoma and completely abrogates breast cancer.
Keyphrases
- gold nanoparticles
- cancer therapy
- radiation therapy
- reduced graphene oxide
- sensitive detection
- drug delivery
- locally advanced
- radiation induced
- dna damage
- high resolution
- rectal cancer
- squamous cell carcinoma
- type diabetes
- cell death
- magnetic resonance imaging
- drug release
- breast cancer risk
- metabolic syndrome
- computed tomography
- magnetic resonance
- quantum dots
- drug induced
- adipose tissue