Multiple metal exposures associate with higher amyotrophic lateral sclerosis risk and mortality independent of genetic risk and correlate to self-reported exposures: a case-control study.

Dae Gyu JangJohn F DouEmily J KoubekSamuel TeenerLili ZhouKelly M BakulskiBhramar MukherjeeStuart A Batterman Eva L Feldman Stephen A Goutman

Published in: Journal of neurology, neurosurgery, and psychiatry (2024)

Metals in plasma and urine associated with increased ALS risk and reduced survival, independent of genetic risk, and correlated with occupational and non-occupational metal exposures. These data underscore the significance of metal exposure in ALS risk and progression.

Keyphrases

amyotrophic lateral sclerosis
air pollution
type diabetes
gene expression
risk factors
risk assessment
human health