Risk of metachronous colorectal cancer following colectomy in Lynch syndrome: a systematic review and meta-analysis.
Chukwuemeka C AneleS O AdegbolaA AskariA RajendranS K ClarkA LatchfordO D FaizPublished in: Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland (2018)
This result suggests that extended colectomy reduces the risk of mCRC by over four-fold compared with segmental colectomy. mCRC occurred in the segmental group despite postoperative endoscopic surveillance. This needs to be borne in mind when deciding on the appropriate surgical management of LS patients with CRC. We recommend that extended colectomy should be considered for patients with confirmed LS CRC.