Full-spectral genome analysis of natural killer/T cell lymphoma highlights impacts of genome instability in driving its progression.
Zegeng ChenHe HuangHuangming HongHuageng HuangHuawei WengLe YuJian XiaoZhao WangXiaojie FangYuyi YaoJia-Xing YueTongyu LinPublished in: Genome medicine (2024)
The striking differences underlying the mutational landscapes between the primary and relapsed/refractory NKTCL patients highlight the importance of genomic instability in driving the progression of NKTCL. Our newly proposed molecular subtyping system is valuable in assisting patient stratification and novel treatment design towards a better prognosis in the age of precision medicine.
Keyphrases
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- acute lymphoblastic leukemia
- acute myeloid leukemia
- genome wide
- peritoneal dialysis
- optical coherence tomography
- copy number
- magnetic resonance imaging
- patient reported outcomes
- dna methylation
- combination therapy
- patient reported
- dual energy
- contrast enhanced