Human papilloma virus (HPV) integration signature in Cervical Cancer: identification of MACROD2 gene as HPV hot spot integration site.

Maud KamalSonia LameirasMarc DelogerAdeline MorelSophie VacherCharlotte LecerfCélia DupainEmmanuelle JeannotElodie GirardSylvain BaulandeCoraline DubotGemma KenterEkaterina S JordanovaEls M J J BernsGuillaume BataillonMarina PopovicRoman RouzierWulfran CacheuxChristophe Le TourneauAlain NicolasNicolas ServantSuzy M SchollIvan Bièchenull null

Published in: British journal of cancer (2020)

This is to our knowledge the first study assessing the prognostic value of HPV integration in a prospectively annotated CC cohort, which detects a hotspot of HPV integration at MACROD2; involved in impaired PARP1 activity and chromosome instability.

Keyphrases

high grade
cervical cancer screening
endothelial cells
healthcare
dna damage
gene expression
dna repair
genome wide