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Mitotic arrest affects clustering of tumor cells.

Julia BonnetLise RigalOdile MondesertRenaud MorinGaëlle CorsautMathieu VigneauBernard DucommunValerie Lobjois
Published in: Cell division (2021)
Altogether, our results suggest that mitotic arrest induced by microtubule-targeting anticancer drugs prevents cancer cell clustering and therefore, could reduce the metastatic potential of circulating tumor cells.
Keyphrases
  • cell cycle
  • circulating tumor cells
  • single cell
  • cell proliferation
  • rna seq
  • squamous cell carcinoma
  • small cell lung cancer
  • circulating tumor
  • cancer therapy
  • human health
  • drug delivery