Synergism of Nikkomycin Z in Combination with Diphenyl Diselenide Against Sporothrix spp.

Vanice Rodrigues Poester Lívia Silveira Munhoz Jéssica Louise Benelli Gabriel Baracy Klafke Cristina Wayne Nogueira Gilson Rogério ZeniDavid A StevensDavid LarwoodMelissa Orzechowski Xavier

Published in: Current microbiology (2021)

We evaluated the in vitro activity of nikkomycin Z (NikZ) in combination with diphenyl diselenide (PhSe)2, two compounds previously shown to have anti-Sporothrix spp. activity. Eighteen isolates of Sporothrix spp. were tested in checkerboard assays. Synergism for inhibition and killing Sporothrix spp. occurred in 100% and 89% of the isolates, respectively. The anti-Sporothrix spp. activity of this combination provides a rationale for in vivo studies to evaluate the application of both compounds in sporotrichosis treatment.

Keyphrases

clinical trial
high throughput
genetic diversity
single cell