Negative regulation of glial Tim-3 inhibits the secretion of inflammatory factors and modulates microglia to antiinflammatory phenotype after experimental intracerebral hemorrhage in rats.

Zhou-Qing ChenHao YuHai-Ying LiHai-Tao ShenXiang LiJu-Yi ZhangZhu-Wei ZhangZhong WangHeng Gao

Published in: CNS neuroscience & therapeutics (2019)

Tim-3 may be an important link between neuroinflammation and microglia polarization through Tim-3/Gal-9 and TLR-4 signaling pathways which induced SBI after ICH.

Keyphrases

inflammatory response
neuropathic pain
lipopolysaccharide induced
lps induced
signaling pathway
toll like receptor
brain injury
high glucose
traumatic brain injury
immune response
oxidative stress
spinal cord
spinal cord injury
pi k akt
drug induced
nuclear factor
induced apoptosis