Severe COVID-19 is a T cell immune dysregulatory disorder triggered by SARS-CoV-2.

Rohan AmeratungaSee-Tarn WoonRichard SteeleKlaus LehnertEuphemia Y LeungAnna E S Brooks

Published in: Expert review of clinical immunology (2022)

T cells play a crucial role in both the outcome of COVID-19 as well as the protective response to vaccines. Vaccines do not prevent infection but reduce the risk of a chaotic and destructive cellular immune response to the virus. Severe COVID-19 should be considered a virus-induced secondary immune dysregulatory disorder of cellular immunity, with broad host susceptibility. This perspective of COVID-19 will lead to better diagnostic tests, vaccines, and therapeutic strategies in the future.

Keyphrases

sars cov
coronavirus disease
respiratory syndrome coronavirus
early onset
drug induced
endothelial cells