Analysis of human brain tissue derived from DBS surgery.
Salla M KangasJaakko TeppoMaija J LahtinenAnu SuorantaBishwa GhimirePirkko MattilaJohanna UusimaaMarkku VarjosaloJani KatiskoReetta HinttalaPublished in: Translational neurodegeneration (2022)
The instruments used during routine DBS surgery are a useful source for obtaining fresh brain tissues from living patients. This approach overcomes the issues that arise from using postmortem tissues, such as the effect of postmortem interval on transcriptomic and proteomic landscape of the brain, and can be used for studying molecular aspects of DBS-treatable diseases.
Keyphrases
- deep brain stimulation
- minimally invasive
- coronary artery bypass
- end stage renal disease
- gene expression
- resting state
- white matter
- ejection fraction
- newly diagnosed
- single cell
- patient reported outcomes
- functional connectivity
- prognostic factors
- cerebral ischemia
- rna seq
- multiple sclerosis
- percutaneous coronary intervention
- subarachnoid hemorrhage