Gold Ion Beam Milled Gold Zero-Mode Waveguides.

Troy C MessinaBernadeta R SrijantoCharles Patrick Collier Ivan I KravchenkoChristopher I Richards

Published in: Nanomaterials (Basel, Switzerland) (2022)

Zero-mode waveguides (ZMWs) are widely used in single molecule fluorescence microscopy for their enhancement of emitted light and the ability to study samples at physiological concentrations. ZMWs are typically produced using photo or electron beam lithography. We report a new method of ZMW production using focused ion beam (FIB) milling with gold ions. We demonstrate that ion-milled gold ZMWs with 200 nm apertures exhibit similar plasmon-enhanced fluorescence seen with ZMWs fabricated with traditional techniques such as electron beam lithography.

Keyphrases

single molecule
electron microscopy
atomic force microscopy
living cells
monte carlo
energy transfer
high resolution
photodynamic therapy
liver fibrosis