Kinin B1 receptor deficiency promotes enhanced adipose tissue thermogenic response to β3-adrenergic stimulation.
Jéssica BranquinhoRaquel L NevesRenan P MartinJúlia G ArataClarissa A BittencourtRonaldo C AraújoMarcelo Y IcimotoJoão B PesqueroPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2024)
B1R deficiency induced metabolic and gene expression alterations in adipose tissue, activating thermogenic pathways and increasing energy metabolism. B1R antagonists emerge as promising therapeutic targets for regulating obesity and associated metabolic disorders, such as inflammation and diabetes.
Keyphrases
- adipose tissue
- insulin resistance
- gene expression
- type diabetes
- high fat diet
- metabolic syndrome
- oxidative stress
- dna methylation
- glycemic control
- high fat diet induced
- cardiovascular disease
- diabetic rats
- high glucose
- weight loss
- signaling pathway
- weight gain
- drug induced
- endothelial cells
- binding protein
- physical activity