Dose-dependent naloxone-induced morphine withdrawal symptoms in opioid-dependent males-a double-blinded, randomized study.

Stefan WeisshaarLaura BrandtBrigitte LitschauerSafoura Sheik-RezaeiLaura MoserGünther NirnbergerElisabeth KühbergerUlrike BauerChrista FirbasGhazaleh GouyaMichael WolztGabriele Fischer

Published in: British journal of clinical pharmacology (2020)

Morphine-naloxone 100:1 effectively suppresses the pleasurable effects of intravenous morphine and results in an aversive withdrawal reaction. A lower naloxone concentration as used in morphine-naloxone 200:1 does not appear to be appropriate to prevent intravenous morphine misuse.

Keyphrases

chronic pain
pain management
diabetic rats
physical activity
high glucose
low dose
drug induced