Adipose Derived Mesenchymal Stem Cells-Derived Mitochondria Transplantation Ameliorated Erectile Dysfunction Induced by Cavernous Nerve Injury.

Jiancheng Zhai Zehong Chen Peng Chen Wende Yang Hongbo Wei

Published in: The world journal of men's health (2023)

ADSCs-mito transplantation significantly ameliorated ED induced by CNI, with similar potency to ADSCs treatment. The ADSCs-mito might exert their effects via anti-oxidative stress, anti-apoptosis and modulating energy metabolism of CCSMCs. Mitochondrial transplantation should be a promising therapeutic method for treating CNI ED in the future.

Keyphrases

oxidative stress
mesenchymal stem cells
emergency department
cell therapy
cell death
bone marrow
cell cycle arrest
cell proliferation
peripheral nerve
heat shock
smoking cessation