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The potential of phosphorylated α-synuclein as a biomarker for the diagnosis and monitoring of multiple system atrophy.

Toufik Abdul-RahmanRanferi Eduardo Herrera-CalderónArjun AhluwaliaAndrew Awuah WirekoTomas FerreiraJoecelyn Kirani TanMaximillian WolfsonShankhaneel GhoshViktoriia HorbasVandana GargAsma PerveenMarios PapadakisGhulam Md AshrafAthanasios Alexiou
Published in: CNS neuroscience & therapeutics (2024)
The p-syn stands out as a promising biomarker for MSA. It is found in oligodendrocytes and shows a correlation with disease severity and progression. However, further research and validation studies are necessary to establish p-syn as a reliable biomarker for MSA. If proven, p-syn could significantly contribute to early diagnosis, disease monitoring, and assessing treatment response.
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