Mitochondrial stress in advanced fibrosis and cirrhosis associated with chronic hepatitis B, chronic hepatitis C, or nonalcoholic steatohepatitis.

Dimitri Loureiro Issam ToutStéphanie NarguetCheikh Mohamed BedMorgane RoinardAhmad SleimanNathalie BoyerNathalie Pons-KerjeanCorinne CastelnauNathalie GiulyDorothy TonuiVassili SoumelisJamel El BennaPatrick Soussan Richard Moreau Valérie Paradis Abdellah MansouriTarik Asselah

Published in: Hepatology (Baltimore, Md.) (2022)

Our results emphasized the importance of mitochondrial OS, mtDNA damage, and associated alterations in mitochondrial function and dynamics in AF or cirrhosis in CHB and NASH. Mitochondria might be a target in drug development to stop fibrosis progression.

Keyphrases

liver fibrosis
oxidative stress
hepatitis b virus
atrial fibrillation
mitochondrial dna
cell death
copy number
reactive oxygen species
gene expression
heat stress
genome wide