Irijimasides A-E, Macrolide Glycosides from an Okeania sp. Marine Cyanobacterium.
Aki YamanoNoriyuki NatsumeMiki YamadaShimpei SumimotoArihiro IwasakiKiyotake SuenagaToshiaki TeruyaPublished in: Journal of natural products (2020)
Irijimasides A-E (1-5), a series of new 14-membered macrolide glycosides, were isolated from a marine cyanobacterium collected in Okinawa. The gross structures of 1-5 were established by spectroscopic analysis, including 2D NMR, while absolute stereostructures were determined based on NOESY spectra, chemical derivatization, and ECD data. All five macrolides suppressed receptor activator of nuclear factor-κB ligand (RANKL)-induced tartrate-resistant acid phosphatase (TRAP) activity in mouse RAW264 macrophage cells, indicating that these compounds inhibit osteoclast formation.
Keyphrases
- nuclear factor
- toll like receptor
- induced apoptosis
- high resolution
- magnetic resonance
- cell cycle arrest
- high glucose
- molecular docking
- adipose tissue
- electronic health record
- diabetic rats
- endoplasmic reticulum stress
- inflammatory response
- gas chromatography mass spectrometry
- big data
- oxidative stress
- immune response
- drug induced
- liquid chromatography
- high performance liquid chromatography
- bone loss
- solid state
- protein kinase
- signaling pathway
- data analysis
- children with cerebral palsy
- molecular dynamics
- endothelial cells