ADAMTS-7 Modulates Atherosclerotic Plaque Formation by Degradation of TIMP-1.
M Amin SharifiMichael WiererTan An DangJelena MilicAldo MoggioNadja SachsMoritz von ScheidtJulia HinterdoblerPhilipp MüllerJulia WernerBarbara StillerZouhair AherrahrouJeanette ErdmannAndrea ZalianiMira GraettingerJeanette ReinshagenSheraz GulPhilip GribbonLars MaegdefesselJürgen BernhagenHendrik B SagerMatthias MannHeribert SchunkertThorsten KesslerPublished in: Circulation research (2023)
ADAMTS-7, which is induced in unstable atherosclerotic plaques, decreases TIMP-1 stability reducing its inhibitory effect on MMP-9, which is known to promote collagen degradation and is likewise associated with coronary artery disease. Disrupting the interaction of ADAMTS-7 and TIMP-1 might be a strategy to increase collagen content and plaque stability for the reduction of atherosclerosis-related events.