Plasma-derived FVIII/VWF complex shows higher protection against inhibitors than isolated FVIII after infusion in haemophilic patients: A translational study.

Maria Isabel BravoAlba PérezAida RaventósSalvador GranchaJuan Ignacio JorqueraNora Viviana Butta Maria Teresa Alvarez-RomanMontserrat CostaTodd WillisVictor Jimenez Yuste

Published in: Haemophilia : the official journal of the World Federation of Hemophilia (2022)

Data indicate that FVIII+VWF complexes assembled in the circulation after rFVIII infusion are not equivalent to the naturally formed complex in pdFVIII/VWF. Therefore, rFVIII infused into HA patients with inhibitors would be less protected by VWF than the FVIII in pdFVIII/VWF concentrates.

Keyphrases

end stage renal disease
low dose
ejection fraction
chronic kidney disease
newly diagnosed
prognostic factors
peritoneal dialysis
big data