Age-associated phenotypic imbalance in TCD4 and TCD8 cell subsets: comparison between healthy aged, smokers, COPD patients and young adults.
Juliana Ruiz FernandesThalyta Nery Carvalho PintoLiã Barbara ArrudaCibele Cristine Berto Marques da SilvaCelso Ricardo Fernandes de CarvalhoRegina Maria Carvalho PintoAlberto José da Silva DuarteGil BenardPublished in: Immunity & ageing : I & A (2022)
Our study extends previous findings by showing that COPD patients have cells expressing a full range of late differentiated, senescent or exhausted phenotypes encompassing all TCD4 and TCD8 subsets, consistent with a premature immunosenescence phenotype. Surprisingly, the smokers group's results suggest that moderate to heavy chronic cigarette smoking did not accelerate the pace of immunosenescence as compared with the Healthy aged.