Satellite cells: regenerative mechanisms and applicability in muscular dystrophy.
Gustavo Torres de SouzaRafaella de Souza Salomão ZanetteDanielle Luciana Aurora Soares do AmaralFrancisco Carlos da GuiaClaudinéia Pereira MarandubaCamila Maurmann de SouzaErnesto da Silveira Goulart GuimarãesJoão Vitor Paes RettoreNatana Chaves RabeloAntônio Márcio Resende do CarmoFernando de Sá SilvaCarlos Magno da Costa MarandubaPublished in: Stem cells international (2015)
The satellite cells are long regarded as heterogeneous cell population, which is intimately linked to the processes of muscular recovery. The heterogeneous cell population may be classified by specific markers. In spite of the significant amount of variation amongst the satellite cell populations, it seems that their activity is tightly bound to the paired box 7 transcription factor expression, which is, therefore, used as a canonical marker for these cells. Muscular dystrophic diseases, such as Duchenne muscular dystrophy, elicit severe tissue injuries leading those patients to display a very specific pattern of muscular recovery abnormalities. There have been works on the application of precursors cells as a therapeutic alternative for Duchenne muscular dystrophy and initial attempts have proven the cells inefficient; however later endeavours have proposed solutions for the experiments improving significantly the results. The presence of a range of satellite cells populations indicates the existence of specific cells with enhanced capability of muscular recovery in afflicted muscles.
Keyphrases
- induced apoptosis
- duchenne muscular dystrophy
- cell cycle arrest
- transcription factor
- stem cells
- endoplasmic reticulum stress
- cell death
- cell therapy
- mesenchymal stem cells
- early onset
- chronic kidney disease
- signaling pathway
- ejection fraction
- end stage renal disease
- oxidative stress
- cell proliferation
- drug induced
- patient reported