Untargeted lipidomic features associated with colorectal cancer in a prospective cohort.

Kelsi PerttulaCourtney SchiffmanWilliam M B EdmandsLauren PetrickHasmik GrigoryanXiaoming CaiMarc J GunterAlessio NaccaratiSilvia PolidoroSandrine DudoitPaolo VineisStephen M Rappaport

Published in: BMC cancer (2018)

Of the nine selected LC-MS features, four appear to be involved in CRC etiology and merit further investigation in prospective studies of CRC. Four other features appear to be related to progression of the disease (reverse causality), and may represent biomarkers of value for early detection of CRC.

Keyphrases

mass spectrometry
high resolution
case control
high resolution mass spectrometry
electronic health record