Aerobic C-C Bond Cleavage of Allylic Alcohols via Co-Catalyzed Hydrogen Atom Transfer.

Meng DengMengqi ChuNan LiGuohui SunFei LiDade GuoGuohui KangBaoming Ji

Published in: Organic letters (2023)

A simple, efficient method has been developed for the Co III -H-catalyzed aerobic C-C bond cleavage of tertiary allylic alcohols to access ketones. This novel approach presents excellent chemoselectivity, good functional group compatibility, and high yields. This reaction occurs through a HAT-initiated peroxide intermediate, and an adjacent glycol-type diradical fragmentation process is recommended.

Keyphrases

electron transfer
room temperature
dna binding
high intensity
molecular dynamics
transition metal
transcription factor