AhR-STAT3-Hmox1/Ptgs2 signaling pathway may restrict ferroptosis and improve hMSC accumulation and efficacy in mice liver.

Li HanChenhui MaZhitao WuHuiming XuHai LiGuoyu Pan

Published in: British journal of pharmacology (2023)

Overall, these findings revealed that ferroptosis was critical to hMSC cell fate; the inhibition of AhR may reduce liver ferroptosis which enhanced MSCs' exposure and therapeutic effects.

Keyphrases

cell death
cell fate
signaling pathway
mesenchymal stem cells
epithelial mesenchymal transition
cell proliferation
single cell
type diabetes
skeletal muscle
endoplasmic reticulum stress