Caspase-4/11-Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension.

Yusi WuBingjie PanZhen ZhangXiaohui LiYiping LengYong JiKun SunAlex F Chen

Published in: Hypertension (Dallas, Tex. : 1979) (2022)

These observations identified the critical role of caspase-4/11 in the pyroptosis pathway to modulate pulmonary vascular dysfunction and accelerate the progression of PAH. Our findings provide a potential diagnostic and therapeutic target in PAH.

Keyphrases

pulmonary arterial hypertension
pulmonary artery
pulmonary hypertension
cell death
nlrp inflammasome
induced apoptosis
endothelial cells
polycyclic aromatic hydrocarbons
oxidative stress
coronary artery
endoplasmic reticulum stress
human health
high glucose
vascular endothelial growth factor