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Characterization, management, and risk factors of hyperglycemia during PI3K or AKT inhibitor treatment.

Dazhi LiuMichael A WeintraubChristine GarciaMarcus D GoncalvesAnn Elizabeth SiskAlissa CasasJames J HardingStephen HarnicarAlexander DrilonKomal JhaveriJames H Flory
Published in: Cancer medicine (2022)
Hyperglycemia is one of the major on-target side effects of PI3K and AKT inhibitors. It is manageable with antidiabetic medications, treatment interruption and/or dose modification. We summarize pharmacological interventions that may be considered for PI3K/AKT inhibitor induced hyperglycemia. SGLT2-inhibitor may be a particularly effective second-line option after metformin but there is a low risk of euglycemic DKA, which can be deadly. To our knowledge, our report is the largest study of hyperglycemia in patients receiving PI3K/AKT inhibitors.
Keyphrases
  • pi k akt
  • signaling pathway
  • cell proliferation
  • diabetic rats
  • cell cycle arrest
  • risk factors
  • healthcare
  • oxidative stress
  • high glucose
  • cell death
  • drug induced