Flucloxacillin worsens while imipenem-cilastatin protects against vancomycin induced kidney injury in a translational rat model.
Gwendolyn M PaisSylwia MarianskiKimberly ValdezRenz Paulo MelicorJiajun LiuRoxane RohaniJack ChangSteven Y C TongJoshua S DavisMarc H ScheetzPublished in: British journal of pharmacology (2023)
Vancomycin+flucloxacillin caused more kidney injury compared to vancomycin alone and vancomycin+imipenem-cilastatin in a translational rat model as determined by multiple kidney injury biomarkers. The combination of vancomycin+imipenem-cilastatin was nephroprotective.