Mixed Micelles Loaded with Bile Salt: An Approach to Enhance Intestinal Transport of the BCS Class III Drug Cefotaxime in Rats.

Mosab ArafatCathrin KirchhoeferMomir Mikov

Published in: European journal of drug metabolism and pharmacokinetics (2018)

The mixed micellar formulation was able to increase the oral bioavailability of the BCS Class III drug cefotaxime up to fourfold by enhancing drug permeation through the mucosal membrane of the small intestine.

Keyphrases

drug delivery
cancer therapy
adverse drug
emergency department
drug release