Proteomic analysis of diabetes genetic risk scores identifies complement C2 and neuropilin-2 as predictors of type 2 diabetes: the Atherosclerosis Risk in Communities (ARIC) Study.

Brian T SteffenWeihong TangPamela L LutseyRyan T DemmerElizabeth SelvinKunihiro MatsushitaAlanna C MorrisonWeihua GuanMary R RooneyFaye L NorbyNathan PankratzDavid CouperJames S Pankow

Published in: Diabetologia (2022)

Identified proteins may represent viable intervention or pharmacological targets to prevent, reverse or slow type 2 diabetes progression, and further research is needed to pursue these targets.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
genome wide
insulin resistance
gene expression
skeletal muscle
copy number