Genome-Wide Association Meta-Analysis Supports Genes Involved in Valve and Cardiac Development to Associate With Mitral Valve Prolapse.
Mengyao YuSergiy KyryachenkoStephanie DebettePhillippe AmouyelJean-Jacques SchottThierry Le TourneauChristian DinaRussell A NorrisAlbert A HagègeXavier JeunemaitreNabila Bouatia-NajiPublished in: Circulation. Genomic and precision medicine (2021)
We report an updated meta-analysis genome-wide association study for MVP using dense imputation coverage and an improved case-control sample. We describe several loci and genes with MVP spanning biological mechanisms highly relevant to MVP, especially during valve and heart development.