Lineage tracing and single-cell analysis reveal proliferative Prom1+ tumour-propagating cells and their dynamic cellular transition during liver cancer progression.

Lei ZhouKen Ho YuTin-Lok WongZhao ZhangChun Ho ChanJane Hc LoongNoelia CheHua Jian YuKel Vin Tan Man TongElly S NganJoshua Wk HoStephianie Ma

Published in: Gut (2021)

Our study combines in vivo lineage tracing and scRNA-seq to reveal the heterogeneity and dynamics of Prom1+ HCC cells, providing insights into the mechanistic role of malignant CSC-like cells in HCC progression.

Keyphrases

single cell
rna seq
induced apoptosis
high throughput
cell cycle arrest
genome wide
oxidative stress
cell proliferation