AEG-1 Contributes to Metastasis in Hypoxia-Related Ovarian Cancer by Modulating the HIF-1alpha/NF-kappaB/VEGF Pathway.

Xiaoyu YuYan WangHuilei QiuHongtao SongDi FengYang JiangShuzhe DengHongxue MengJing-Shu Geng

Published in: BioMed research international (2018)

As an independent prognostic factor, AEG-1 was found to be significantly associated with hypoxia in ovarian cancer by regulating the HIF-1alpha/NF-kappaB/VEGF pathway. Therefore, AEG-1 may be useful in determining disease stage and prognosis in ovarian cancer.

Keyphrases

endothelial cells
prognostic factors
signaling pathway
vascular endothelial growth factor
lps induced
pi k akt
nuclear factor
inflammatory response