Elevated TAB182 enhances the radioresistance of esophageal squamous cell carcinoma through G2-M checkpoint modulation.

Yuandong CaoAidi GaoXiaoqing LiHan MinChao HeXinchen SunWei-Qun DingJundong Zhou

Published in: Cancer medicine (2021)

TAB182 potentiates the radioresistance of ESCC cells by modulating the G2-M checkpoint through its interaction with FHL2. Thus, TAB182 may become an ideal biomarker and therapeutic target of ESCC radiotherapy.

Keyphrases

dna damage
cell cycle
induced apoptosis
dna damage response
cell cycle arrest
early stage
signaling pathway
cancer stem cells
radiation therapy
locally advanced
dna repair
radiation induced
oxidative stress
squamous cell carcinoma