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Organotrifluoroborate enhances tumor targeting of fibroblast activation protein inhibitors for targeted radionuclide therapy.

Yu LiuHaocheng TangTianchi SongMengxin XuJunyi ChenXi-Yang CuiYuxiang HanZhu LiZhibo Liu
Published in: European journal of nuclear medicine and molecular imaging (2023)
The organotrifluoroborate linker may be of importance to optimize FAP-targeted radiopharmaceuticals, and the short half-lived α-emitters may be of choice for the rapid-cleared small molecule-based radiopharmaceuticals.
Keyphrases
  • small molecule
  • cancer therapy
  • protein protein
  • drug delivery
  • loop mediated isothermal amplification
  • mesenchymal stem cells