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Impaired Dynamics of Positional and Contextual Neural Coding in an Alzheimer's Disease Rat Model.

Athira NatarajAnnu KalaStephanie Lissette Proskauer PenaKarel JezekKarel Blahna
Published in: Journal of Alzheimer's disease : JAD (2024)
Overall, the results shed light on the nature of impairment at both the single-cell and population levels in the transgenic AD model. In addition to the observed spatial coding inaccuracy, the findings reveal a significantly impaired ability to adaptively modify and refine newly stored hippocampal memory patterns.
Keyphrases
  • single cell
  • rna seq
  • high throughput
  • working memory
  • cognitive decline
  • genome wide
  • room temperature
  • gene expression
  • blood brain barrier