Collagen type IV remodelling gender-specifically predicts mortality in decompensated cirrhosis.
Jennifer LehmannMichael PraktiknjoMette Juul NielsenRobert SchierwagenCarsten MeyerDaniel ThomasFrancesco VioliChristian P StrassburgFlemming BendtsenSøren MøllerAleksander KragMorten Asser KarsdalDiana Julie LeemingJonel TrebickaPublished in: Liver international : official journal of the International Association for the Study of the Liver (2019)
This study shows that markers of collagen type IV remodelling do not accumulate in severe renal dysfunction. Although collagen type IV degradation markers derive from the liver, portal venous C4M levels are relevant for survival. Moreover, it demonstrates that circulating C4M shows gender-specific profiles, which can independently predict survival in female patients with decompensated cirrhosis.