Use of Magnetotactic Bacteria as an MRI Contrast Agent for In Vivo Tracking of Adoptively Transferred Immune Cells.
Andrea NuschkeCaitrin Sobey-SkeltonBassel DawodBrianna KellyMarie-Laurence TremblayChrista DavisJames A RiouxKimberly Dawn BrewerPublished in: Molecular imaging and biology (2023)
Cells can be labeled with sufficient numbers of MEs to be detectable with MRI without compromising cell viability. Care must be taken at higher concentrations of MEs, which may affect some cell types' functional activity and/or morphology. Immune cells with minimal phagocytic behavior have much lower iron content per cell after incubation with MEs vs SPIO; however, MEs can successfully be used as a contrast agent for phagocytic immune cells.
Keyphrases
- contrast enhanced
- single cell
- magnetic resonance imaging
- magnetic resonance
- cell therapy
- healthcare
- induced apoptosis
- computed tomography
- diffusion weighted imaging
- quality improvement
- cell death
- pet imaging
- oxidative stress
- chronic pain
- iron deficiency
- health insurance
- positron emission tomography
- affordable care act