Atmospheric Pressure Drift Tube Ion Mobility Spectrometry Coupled with Two-Dimensional Tandem Mass Spectrometry.
Robert L SchraderBrett M MarshRobert Graham CooksPublished in: Journal of the American Society for Mass Spectrometry (2021)
Atmospheric pressure drift tube ion mobility was coupled with two-dimensional tandem mass spectrometry (2D MS/MS) in a linear ion trap to simultaneously collect ion mobility and the entire MS/MS data domain. Utilizing ion intensities from precursor ion and neutral loss scan lines, ion mobility spectra of multiple compounds with particular functional groups were acquired in a single experiment. Functional group-specific ion mobility spectra were demonstrated for a standard mixture of lipids. Additionally, ion mobility was used to separate isobaric ions prior to 2D MS/MS. The combination of these two methods offers improvements for the analysis of complex mixtures.
Keyphrases
- tandem mass spectrometry
- ultra high performance liquid chromatography
- ms ms
- high performance liquid chromatography
- gas chromatography
- simultaneous determination
- liquid chromatography
- solid phase extraction
- liquid chromatography tandem mass spectrometry
- high resolution
- high resolution mass spectrometry
- particulate matter
- mass spectrometry
- density functional theory
- quantum dots
- ionic liquid
- magnetic resonance imaging
- electronic health record
- air pollution
- big data
- machine learning